![]() ![]() Although this mechanism is not fully understood, these receptors are believed to be the targets of psychedelics. Chemicals can bind to these receptors in order to stimulate or block the serotonin system. Since serotonin is so widely important in the body, there are molecular regions called serotonin 2A receptors located throughout the central nervous system. In fact, serotonin is associated not just with mood, but also with cognition, sleeping, eating, thermoregulation, memory, and even physiological processes like vomiting. Serotonin is popularly portrayed in the media as being responsible for happiness, but in reality, its functionality is much more complex and widespread. Psychedelics are known to primarily affect serotonin, a chemical messenger that helps nerve cells communicate with other cells in the body. The drug may bind to a molecular region known as the serotonin 2A receptor, and cause the cortex to become excited and form new neuronal connections. The potential mechanisms of microdosing Figure 1: One potential mechanism for psychedelic drugs. Nevertheless, some scientists are skeptical that these results are spurious, or worse, that microdosing may even be harmful. Despite the small amount of drug taken, there is evidence to suggest that microdosing can still bring about some of the benefits observed with full-dose treatment without causing the intense and sometimes negative hallucinatory experiences. Microdosing is when patients take a dose of psychedelics that is too small to produce any perceptible effects, generally between 5 to 10% of a standard dose. ![]() Landmark trials from 20 have already shown that LSD and psilocybin respectively improved mood and anxiety in patients with various life-threatening illnesses for up to a year after treatment, with many more studies underway.Īlongside this renewed interest in psychedelics is an increasing popular approach known as microdosing. After a nearly 40 year pause in this work, scientists are beginning to resume this research. 1971 Controlled Substances Act was passed that much of this research came to a grinding halt. This psychiatric interest in psychedelics is nothing new: in the 1950s and 60s, thousands of patients were experimentally given various psychedelics to treat alcoholism and other mental health disorders. Popular psychedelics include LSD (lysergic acid diethylamide), magic mushrooms (containing the psychedelic psilocybin), and DMT (N,N-dimethyltryptamine, part of the spiritual medicine ayahuasca), all of which can cause intense psychological experiences colloquially known as “trips.” However, there is an emerging push within the scientific community to study these known recreational drugs as treatments for psychiatric conditions that could potentially be more effective with fewer side effects than traditional psychiatric medications. When you hear the term “psychedelics,” you might think of hallucinogenic and mystical experiences. ![]()
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